TH+immune+response+SAC

Set up this page however you wish to show the progress of your research and development of your presentation on an aspect of the immune response. Question2: hey voj..with the application did u want scientists names of who discovered the application/researched it plus dates? or just the outline of the application? How much detail you go into depends on whether you have time and how important you think the information is in addressing the criteria. My view is that acknowledging scientists who have made discoveries helps put the application into perspective sometimes.VM

=  **General outlook on my section of immunity:**   **  Non Specific Immunity  **= -  General response -  Can be physical, chemical and cellular defences that prevent microbes from entering the body -  Present at birth (innate response) this also means they are always present and are not produced by prior contacts with a pathogen.. -  Acts the same way irrespective of the invading pathogen, thus protect against a wide range variety of pathogenic organisms -     Has no memory about previous infections -  Level of response is the same for each infection = ** 1st line of defence (external) **** Prevention: Acts as a barrier in the immune response ** =
 * Things to do for SAC:**
 * 1)    get topic (Tuesday)
 * 2)    Research topic thoroughly
 * 3)    Distinguish between non-specific and specific/overall immune response
 * 4)    Find links to the application of (create diagrams)
 * 5)    give example an improvement in medicine (in terms or my topic)
 * 6)     make glossary of terminology which will be used in my speech
 * 7)     create an interesting/innovative way to structure/present my SAC (make sure its not boring  J   - aim is to keep everyone awake/informed)
 * Speech Plan: **
 * 1) Open with a general explanation of the immune system
 * 2)  Describe key components of overall immunity- use of diagram here
 * 3)  Then Introduce my area (non-specific immunity)
 * 4) Go into detail on my area in non-specific immunity - second line of defense AND where it fits in with the overall immune response (i.e. compared to overall immunity/1st/2nd/3rd lines of defence/specific vs. non specific etc...)
 * 5) Then talk about an application = Colony Stimulating Factors (add diagram/visual aid/handout here) PLUS understanding the aspect that has led to an improvement in medicine
 * 6) Sum up about my area (add smile here)

The stomach contains enzymes and strong acids which kills many bacteria || Cilia lining trachea move upwards || Moving fluids - urine flush out pathogens || Nostril hairs (trap pathogens) Tears and saliva contains lysosomes, an enzyme that causes bacteria to lyse or burst. ||
 * **Point of entry for pathogen** || **Manner of transmission for pathogen** || **Barriers or mechanisms to prevent entry of pathogens** ||
 * **Skin (intact)** || **Direct contact** || Keratinised skin cells, rapid blood clotting, raping wound healing, antiseptic in oil ||
 * **Digestive system** || **Ingested food or drink** || Lysosomes in salvia
 * **Respiratory system** || **Water droplets in the air** || Mucous traps dirt and macroscopic pathogens
 * **Reproductive tract/urinary tract** || **Sexual contact** || Mucous containing acids
 * **Sense organs** || **Direct contact** || Ear wax and hairs

= ** 2nd line of defence (internal) **** Woops! They got in: Physiological and Chemical mechanisms ** =

-  Kills some pathogens -  Increases the activity if sine lymphocytes and phagocytes -  Speeds up the death of virus infected cells. || -   interfering with virus replication -  making affected cells more resistant to viruses -  stimulating macrophages to destroy virus infected cells || -directly by the presence of pathogens - when antigens and antibodies combine || Activated complement proteins may: -  lyse (dissolves) pathogens cell walls -  coat pathogens, making them easier for phagocytes to ingest -  attract leukocytes to the site of infection -  stimulate the release of histamine || Histamine causes: -  Dilation of blood vessels in the affected area -  Increased permeability of capillaries. ||
 * || **Defences Mechanism** || ** Action ** ||
 * ** Physiological ** || **Fever:** macrophages release chemicals which reset the body’s thermostat in the hypothalamus, allowing temperature to rise || High temperature helps recovery as it:
 * ** Chemical ** || **Interferon:** are a group of antiviral chemicals, produced by some cells which have been infected with viruses || The can fight viral infection by:
 * || **Complement proteins:** there are about 20 complement proteins present in body fluids. They may be activate to fight infection:
 * ** Cellular ** || **Phagocytes:** phagocytes are white blood cells (neutrophils and monocytes/macrophages) some move to any site of infection or inflammations. Some macrophages do not travel in the blood, but lie in wait for pathogens in the tissues e.g. lungs || Phagocytes engulf, ingest digest and destroy invading pathogens, damaged cells and debris. They can destroy up to 100 bacteria before dying themselves. ||
 * || **Natural Killer (NK) Cells:** a type of lymphocyte, which provide some protection from viruses and cancers || They can destroy cells which have been infected with viruses. They also destroy some tumour cells ||
 * || **Mast Cells:** large cells in connective tissue, filled with granules (histamine). They are important in the inflammatory response || They release histamine in response to injury and in allergic reactions
 * || **Basophils:** granular leukocytes present in the blood. They are important in the inflammatory response || They release histamine and serotonin ||
 * || **Platelets:** cell fragments, circulating in the blood || They too release histamine and also aid in blood clotting. ||

=** GLOSSARY: APPLICATION: DIAGRAMS/VISUAL AIDS: **=

Question1: hey voj.. could i show a little 4 minute **very general** overview of the whole immune response as my opening and then go into where my section (non-specific) relates to the entire system?? or is it too long?? - just trying to think of something different so the class doesnt have to hear the same thing 9 times over.

I think that 4min is too long given that your talk is 5-10min. The aim is for you to have to explain things. A video is fine but you should keep it to about a 1min or 2. And you will all explain things in different ways anyway. VM