AH+immune+response+SAC

Set up this page however you wish to show the progress of your research and development of your presentation on an aspect of the immune response.

** **__GENERAL PLAN FOR SPEECH__** - Our body's bone marrow, and why it may need to be transplanted - use bone marrow diagram - Define allogeneic bone marrow transplant, and briefly describe the process involved (emphasis on TISSUE TYPING) - use diagram - Introduce GVHD as a complication of an allogeneic bone marrow transplant - Why does GVHD occur? - discuss CELL-MEDIATED IMMUNE RESPONSE and explain the term 'HLA system' - use diagram - Mention the difference between acute GVHD and chronic GVHD - Methods of prevention - link back to tissue typing and also immunosuppresants used, with emphasis on cyclosporin - Discuss the advancements in treatment of autoimmune diseases and brain damage with the use of cyclosporin A
 * // Important Points/Concepts to address: //**
 * Allogeneic Transplant (BMT) – a transplant from a donor, eg. Sibling
 * Bone Marrow – spongy tissue found within bones. Contains STEM CELLS that manufacture the body’s blood cells: leukocytes (WBC’s), erythrocytes (RBC’s) and platelets.
 * The HLA (Human Leukocyte Antigen) System = **differentiation between ‘self’ and ‘non-self’**
 * ** CELL-MEDIATED IMMUNE RESPONSE **
 * Chronic GVHD/Acute GVHD
 * Tissue Typing, ensuring the ‘best match’ - *You can get GVHD even if the donor is a sibling*
 * Immunosuppressants and **cyclosporine** ** à MEDICAL ADVANCEMENT **
 * Visual Aids: bone marrow, method of alogeneic transplantation, HLA markers on cells & cause of GVHD (donor immune system attacking recipient's body cells)
 * QUESTIONS TO ADDRESS: **
 * 1) ** Why do people require bone marrow transplants? **
 * 2) ** Why does GVHD occur? (Cell-mediated immune response) **
 * 3) ** Do all people who receive bone marrow transplants develop GVHD? **
 * 4) ** What are some methods of prevention used? (Tissue Typing) **
 * 5) ** How is GVHD treated? **
 * 6) ** How has Cyclosporin A contributed to advancements in medicine? **
 * __ GVHD RISK FACTORS: __**
 * A bone marrow donor who is completely unrelated to the recipient
 * A donor who is mismatched (tissue typing procedure incorrect)
 * Age – older recipients are more at risk to develop GVHD
 * A bone marrow donor who is of a different gender to the recipient
 * If a recipient is CMV positive (cytomegalovirus) – people who are positive have CMV antibodies in their blood, and GVHD can develop if the recipient is negative

Information received from: 1. http://www.marrow.org/PATIENT/Plan_Life_after_Tx/Managing_Long-Term_Effects_of_/Graft-Versus-Host_Disease/index.html 2. http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm 3. http://www.medicalistes.org/gvhd/docs/what_is_gvhd.html Diagrams: 1. Bone marrow: www.nlm.nih.gov 2. HLA: www.immunology.klimov.tom.ru  3. Allogeneic Bone Marrow Transplantation process:  www.makna.org.my