Set up this page however you wish to show the progress of your research and development of your presentation on an aspect of the immune response.
Important Points/Concepts to address:
Allogeneic Transplant (BMT) – a transplant from a donor, eg. Sibling
Bone Marrow – spongy tissue found within bones. Contains STEM CELLS that manufacture the body’s blood cells: leukocytes (WBC’s), erythrocytes (RBC’s) and platelets.
The HLA (Human Leukocyte Antigen) System = differentiation between ‘self’ and ‘non-self’
CELL-MEDIATED IMMUNE RESPONSE
Chronic GVHD/Acute GVHD
Tissue Typing, ensuring the ‘best match’ - *You can get GVHD even if the donor is a sibling*
Immunosuppressants and cyclosporineà MEDICAL ADVANCEMENT
Visual Aids: bone marrow, method of alogeneic transplantation, HLA markers on cells & cause of GVHD (donor immune system attacking recipient's body cells)
QUESTIONS TO ADDRESS:
Why do people require bone marrow transplants?
Why does GVHD occur? (Cell-mediated immune response)
Do all people who receive bone marrow transplants develop GVHD?
What are some methods of prevention used? (Tissue Typing)
How is GVHD treated?
How has Cyclosporin A contributed to advancements in medicine?
GVHD RISK FACTORS:
A bone marrow donor who is completely unrelated to the recipient
A donor who is mismatched (tissue typing procedure incorrect)
Age – older recipients are more at risk to develop GVHD
A bone marrow donor who is of a different gender to the recipient
If a recipient is CMV positive (cytomegalovirus) – people who are positive have CMV antibodies in their blood, and GVHD can develop if the recipient is negative
GENERAL PLAN FOR SPEECH - Our body's bone marrow, and why it may need to be transplanted - use bone marrow diagram
- Define allogeneic bone marrow transplant, and briefly describe the process involved (emphasis on TISSUE TYPING) - use diagram
- Introduce GVHD as a complication of an allogeneic bone marrow transplant
- Why does GVHD occur? - discuss CELL-MEDIATED IMMUNE RESPONSE and explain the term 'HLA system' - use diagram
- Mention the difference between acute GVHD and chronic GVHD
- Methods of prevention - link back to tissue typing and also immunosuppresants used, with emphasis on cyclosporin
- Discuss the advancements in treatment of autoimmune diseases and brain damage with the use of cyclosporin A
Important Points/Concepts to address:
- Allogeneic Transplant (BMT) – a transplant from a donor, eg. Sibling
- Bone Marrow – spongy tissue found within bones. Contains STEM CELLS that manufacture the body’s blood cells: leukocytes (WBC’s), erythrocytes (RBC’s) and platelets.
- The HLA (Human Leukocyte Antigen) System = differentiation between ‘self’ and ‘non-self’
- CELL-MEDIATED IMMUNE RESPONSE
- Chronic GVHD/Acute GVHD
- Tissue Typing, ensuring the ‘best match’ - *You can get GVHD even if the donor is a sibling*
- Immunosuppressants and cyclosporine à MEDICAL ADVANCEMENT
Visual Aids: bone marrow, method of alogeneic transplantation, HLA markers on cells & cause of GVHD (donor immune system attacking recipient's body cells)QUESTIONS TO ADDRESS:
GVHD RISK FACTORS:
- A bone marrow donor who is completely unrelated to the recipient
- A donor who is mismatched (tissue typing procedure incorrect)
- Age – older recipients are more at risk to develop GVHD
- A bone marrow donor who is of a different gender to the recipient
- If a recipient is CMV positive (cytomegalovirus) – people who are positive have CMV antibodies in their blood, and GVHD can develop if the recipient is negative
GENERAL PLAN FOR SPEECH- Our body's bone marrow, and why it may need to be transplanted - use bone marrow diagram
- Define allogeneic bone marrow transplant, and briefly describe the process involved (emphasis on TISSUE TYPING) - use diagram
- Introduce GVHD as a complication of an allogeneic bone marrow transplant
- Why does GVHD occur? - discuss CELL-MEDIATED IMMUNE RESPONSE and explain the term 'HLA system' - use diagram
- Mention the difference between acute GVHD and chronic GVHD
- Methods of prevention - link back to tissue typing and also immunosuppresants used, with emphasis on cyclosporin
- Discuss the advancements in treatment of autoimmune diseases and brain damage with the use of cyclosporin A
Information received from:
1. http://www.marrow.org/PATIENT/Plan_Life_after_Tx/Managing_Long-Term_Effects_of_/Graft-Versus-Host_Disease/index.html
2. http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm
3. http://www.medicalistes.org/gvhd/docs/what_is_gvhd.html
Diagrams:
1. Bone marrow: www.nlm.nih.gov
2. HLA: www.immunology.klimov.tom.ru
3. Allogeneic Bone Marrow Transplantation process: www.makna.org.my