Set up this page however you wish to show the progress of your research and development of your presentation on an aspect of the immune response.

Important Points/Concepts to address:
  • Allogeneic Transplant (BMT) – a transplant from a donor, eg. Sibling
  • Bone Marrow – spongy tissue found within bones. Contains STEM CELLS that manufacture the body’s blood cells: leukocytes (WBC’s), erythrocytes (RBC’s) and platelets.
  • The HLA (Human Leukocyte Antigen) System = differentiation between ‘self’ and ‘non-self’
  • CELL-MEDIATED IMMUNE RESPONSE
  • Chronic GVHD/Acute GVHD
  • Tissue Typing, ensuring the ‘best match’ - *You can get GVHD even if the donor is a sibling*
  • Immunosuppressants and cyclosporine à MEDICAL ADVANCEMENT
Visual Aids: bone marrow, method of alogeneic transplantation, HLA markers on cells & cause of GVHD (donor immune system attacking recipient's body cells)

QUESTIONS TO ADDRESS:
    1. Why do people require bone marrow transplants?
    2. Why does GVHD occur? (Cell-mediated immune response)
    3. Do all people who receive bone marrow transplants develop GVHD?
    4. What are some methods of prevention used? (Tissue Typing)
    5. How is GVHD treated?
    6. How has Cyclosporin A contributed to advancements in medicine?

GVHD RISK FACTORS:
  • A bone marrow donor who is completely unrelated to the recipient
  • A donor who is mismatched (tissue typing procedure incorrect)
  • Age – older recipients are more at risk to develop GVHD
  • A bone marrow donor who is of a different gender to the recipient
  • If a recipient is CMV positive (cytomegalovirus) – people who are positive have CMV antibodies in their blood, and GVHD can develop if the recipient is negative
GENERAL PLAN FOR SPEECH
- Our body's bone marrow, and why it may need to be transplanted - use bone marrow diagram
- Define allogeneic bone marrow transplant, and briefly describe the process involved (emphasis on TISSUE TYPING) - use diagram
- Introduce GVHD as a complication of an allogeneic bone marrow transplant
- Why does GVHD occur? - discuss CELL-MEDIATED IMMUNE RESPONSE and explain the term 'HLA system' - use diagram
- Mention the difference between acute GVHD and chronic GVHD
- Methods of prevention - link back to tissue typing and also immunosuppresants used, with emphasis on cyclosporin
- Discuss the advancements in treatment of autoimmune diseases and brain damage with the use of cyclosporin A

Information received from:
1. http://www.marrow.org/PATIENT/Plan_Life_after_Tx/Managing_Long-Term_Effects_of_/Graft-Versus-Host_Disease/index.html
2. http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm
3. http://www.medicalistes.org/gvhd/docs/what_is_gvhd.html
Diagrams:
1. Bone marrow: www.nlm.nih.gov
2. HLA: www.immunology.klimov.tom.ru
3. Allogeneic Bone Marrow Transplantation process: www.makna.org.my

gvhd.JPG